Joe Biden has rejected suggestions that his Democratic party's shock loss in the Virginia governor's race was a verdict on his presidency.
Mr Biden argued that the miring of his legislative agenda in a Capitol Hill logjam did not sway the outcome.
He cited "Trump voters", schools, jobs and petrol prices as other reasons for the surprise defeat of Terry McAuliffe.
Republican Glenn Youngkin, a political newcomer, came from behind to win the Virginia governor's race on Tuesday.
Meanwhile, the New Jersey governor's race went down to a nail-biting dead heat between the Democratic incumbent, Phil Murphy, and a little-known Republican challenger, Jack Ciattarelli.
US media have projected Mr Murphy will win that race, though his opponent has not yet conceded.
At the White House on Wednesday, Mr Biden was asked whether he accepted any blame for Tuesday's political earthquake in Virginia.
He said voters are "upset and uncertain about a lot of things", including the pandemic, education, the economy and the price of petrol.
Mr Biden conceded Democrats should have passed his signature $1.75tn (£1.3tn) package of social and climate programmes and a $1tn infrastructure bill before Tuesday's vote.
He added: "But I'm not sure I would be able to have changed the number of very conservative folks who turned out in the red districts who were Trump voters."